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Netilmicin

Authoring team

Indications:

  • severe Gram negative infections resistant to gentamicin

Cautions:

  • increase dose interval in renal impairment; if the impairment is severe the dose itself should also be reduced
  • beware drug interactions ! - See curent issue BNF

Cautions:

  • increase dose interval in renal impairment. If the impairment is severe the dose itself should also be reduced
  • beware drug interactions (see current issue BNF)

Contra-indications:

  • pregnancy
  • myasthenia Gravis - aminoglycosides may impair neuromuscular transmission; indeed large doses given during surgery may be responsible for a transient myasthenic syndrome

Side-effects:

  • vestibular damage
  • reversible nephrotoxicity

NB. Both vestibular and renal toxicity are dose related and occur most often in the elderly and in those with renal impairment.

  • hypomagnesaemia in prolonged therapy
  • pseudomembranous colitis

Route of administration;

  • i.m. injection
  • i.v. injection

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