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Treatment of toxoplasmosis

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Treatment is required in circumstances of severe infection, for example, after clinical symptoms for more than 6 weeks, or superimposed upon HIV infection.


  • pyrimethamine - 25-50 mg / 8 h PO for 5 days; then
  • pyrimethamine - 25-50mg / 24h PO for 4 weeks, plus sulphadiazine - 4-6 g / 24h PO

Leucopaenia and thrombocytopaenia may occur with pyrimethamine; give folinic acid, 15 mg daily.

Spiramycin is an alternative to pyrimethamine, but is unsuitable for treating ocular toxoplasmosis. It can cause abdominal pain, nausea and vomiting.

The treatment of toxoplasmosis in specific clinical settings is given in the submenu.

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