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Lymphadenopathy and hypogammaglobulinaemia

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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This condition usually occurs in adolescence, comprising:

  • febrile illness
  • lymphadenopathy
  • idiopathic thrombocytopenic purpura

There is usually spontaneous recovery over a period of a few weeks. However after a period of about 2-3 months the patient may present with recurrent infections, splenomegaly, lymphopaenia and hypogammaglobulinaemia.

Often there is gross generalised lymphadenopathy which on histological examination reveals germinal centre hyperplasia.

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