Laboratory events on cyclosporin A

Event: Value Action

Serum creatinine >30% above Reduce cyclosporin dose baseline by 50%

Serum creatinine >50% above Stop and seek advice baseline

Leucopaenia <3.5*10^9/l Stop & seek advice

Neutropaenia <2.5*10^9/l Stop & seek advice

Thrombocytopaenia <150*10^9/l Stop & seek advice

Macrocytosis >100 Check B12 and folate

Sequential falls >10% on Stop & seek advice in WCC or PMNs 3 occasions

Sequential falls >10% on Stop unless falls are from in platelets 3 occasions a high level, which is a response to treatment