This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Causes of inherited Parkinson's disease

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Despite Parkinson's disease being defined as idiopathic, there are a small proportion of patients who inherit the condition (upto 5% of the cases), usually in an autosomal dominant or -recessive inheritance (1,2).

Inherited conditions usually manifest as early onset Parkinson's disease (1).

The first gene for autosomal dominant Parkinson's disease has been identified. The gene codes for a pre-synaptic protein called alpha-synuclein which is responsible for the autosomal dominant form while autosomal-recessive forms are caused by mutations in the Parkin, DJ-1 and PINK1 genes (2).

Ten genes have been identified. In late 2004 a newer gene (LRRK2) has been identified which is considered to be responsible for the autosomal dominant form (2).


Create an account to add page annotations

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.


Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.