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Alpha - synuclein in Parkinson's disease (PD)

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Alpha-Synuclein in Parkinson's disease

  • alpha Synuclein is a presynaptic neuronal protein that is linked genetically and neuropathologically to Parkinson's disease (PD)

  • deposition of alpha Synuclein and neuronal injury occur many years before the canonical motor signs emerges

  • evidence shows that alpha - synuclein seed amplification assays (SAAs) have the potential to differentiate people with PD from healthy controls
    • results show that the assay classifies people with Parkinson's disease with high sensitivity and specificity (3)

Reference:

  • Stefanis L. alpha-Synuclein in Parkinson's disease. Cold Spring Harb Perspect Med. 2012 Feb;2(2):a009399. doi: 10.1101/cshperspect.a009399. PMID: 22355802; PMCID: PMC3281589.
  • Russo MJ et al.High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson's disease. Acta Neuropathol Commun. 2021 Nov 6;9(1):179. doi: 10.1186/s40478-021-01282-8
  • Siderowf A et al. Assessment of heterogeneity among participants in the Parkinson's Progression Markers Initiative cohort using alpha-synuclein seed amplification: a cross-sectional study. Lancet Neurology May 2023

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