alpha Synuclein is a presynaptic neuronal protein that is linked genetically and neuropathologically to Parkinson's disease (PD)
deposition of alpha Synuclein and neuronal injury occur many years before the canonical motor signs emerges
evidence shows that alpha - synuclein seed amplification assays (SAAs) have the potential to differentiate people with PD from healthy controls
results show that the assay classifies people with Parkinson's disease with high sensitivity and specificity (3)
Reference:
Stefanis L. alpha-Synuclein in Parkinson's disease. Cold Spring Harb Perspect Med. 2012 Feb;2(2):a009399. doi: 10.1101/cshperspect.a009399. PMID: 22355802; PMCID: PMC3281589.
Russo MJ et al.High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson's disease. Acta Neuropathol Commun. 2021 Nov 6;9(1):179. doi: 10.1186/s40478-021-01282-8
Siderowf A et al. Assessment of heterogeneity among participants in the Parkinson's Progression Markers Initiative cohort using alpha-synuclein seed amplification: a cross-sectional study. Lancet Neurology May 2023
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