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Froin's syndrome

Authoring team

Froin syndrome is a phenomenon characterized by the triad of:

  • cerebrospinal fluid (CSF) xanthochromia
  • markedly elevated protein, and
  • hypercoagulation

Foin's syndrome is a sign of blockage of CSF flow in the spine. The commonest causes are:

  • advanced spinal tumour
  • spinal meningitis

Reference:

  1. Diwanji D et al. Froin Syndrome: Unmasking a Rare Case of Spinal Cord Gliosarcoma.AIM Clinical Cases.2025;4:e240569. [Epub 18 March 2025]

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