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Investigations

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One of the major problems in HIV infection in infants is the persistence of maternal antibody, which can only be confidently said to have disappeared at a median age of 18 months.

Other methods are therefore employed, and include:

  • polymerase chain reaction on DNA extracted from lymphocytes
  • HIV culture - which can be slow and expensive
  • measurement of T cell subsets

Diagnosis is usually delayed until two or three months of age, especially with the need to repeat tests to prevent false positives.


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