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Huntington's chorea is characterised by cerebral atrophy with a marked loss of small neurones in the putamen and the caudate nucleus.
There are also changes in neurotransmitters in this disease:
At the cellular level, degenerating neurones have intranuclear inclusions of aggregated huntingtin protein. It is thought that the glutamine residues coded for by the expanded CAG repeats promote an amyloid-like aggregation of the protein.