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Internuclear ophthalmoplegia

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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The internuclear ophthalmoplegia (INO) is a disorder of rapid saccadic eye movements which results from a lesion between:

  • the VIth nerve nucleus in the pons, and
  • the IIIrd nerve nucleus in the midbrain

The nerve bundle which usually connects these nuclei is called the medial longitudinal fasciculus (MLF).

A lesion of the right MLF causes a right INO which is the failure of the right eye to adduct on saccadic lateral gaze to the left.

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