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Treatment and prognosis

Authoring team

Consult expert help.

Ensure good hydration.

Death occurs in the second or third decade from renal failure. Self-mutilation may be reduced by treatment with hydroxytryptophan. Allopurinol reduces uric acid levels, but it does not stop or delay the onset of neurological problems.

Reference:

  1. Nanagiri A. Lesch-Nyhan Syndrome. Treasure Island (FL): StatPearls Publishing. 2025 Jan.

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