Pathology
The pathology of motor neurone disease involves changes that are:
- macroscopic:
- thinning of the anterior roots of the spinal cord
- microscopic:
- loss of neurons in anterior horns, cranial nerve nuclei, and the motor cortex
- among the cranial nuclei, the hypoglossal nucleus, nucleus ambiguus and trigeminal motor nucleus are particularly affected with the third and the fourth nerve nuclei invariably spared
- reduction of corticospinal and corticobulbar tract fibres - corticospinal degeneration is asymmetrical
Reference
- van den Bos MAJ et al. Pathophysiology and Diagnosis of ALS: Insights from Advances in Neurophysiological Techniques. Int J Mol Sci. 2019 Jun 10;20(11)
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