Myasthenia gravis and pregnancy
An increase in symptoms of myasthenia gravis can be seen in pregnancy, but with proper multidisciplinary management, pregnancy is generally not associated with adverse pregnancy outcomes.
In one study of 35 pregnancies in 21 patients with MG (1) there were 30 live births. The symptoms of 50% of the women worsened in the second trimester (typically those with more severe MG); the other 50% either improved or remained stable.
There was an increase in premature rupture of membranes (25.8%) and the most severe complications were abortion (11.4%) and foetal death (2.9%). A caesarean section was performed for two-thirds of births and spinal anaesthesia was used in 73.3%. Neonatal MG was seen in 12.9% of live-born infants, and no predictors were found
Reference:
- Ducci RD, Lorenzoni PJ, Kay CS, et al. Clinical follow-up of pregnancy in myasthenia gravis patients. Neuromuscul Disord. 2017 Apr;27(4):352-57.
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