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Interactions

Authoring team

Interactions of tacrine include:

  • it may block the action of anticholinergic agents
  • action of cholinomimetics may be increased
  • blood concentrations of tacrine may be increased by concurrent use of cimetidine
  • blood concentrations may be reduced by smoking
  • there may be an increased risk of bleeding in patients receiving non-steroidal anti-inflammatory agents
  • tacrine has been reported to increase serum concentrations of theophylline and thus theophylline levels should be monitored when using tacrine and theophylline together

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