Drug-induced vitamin B6 deficiency
Causes include:
- isoniazid - this competitively inhibits the action of pyridoxine, and routine supplementation is recommended
- hydralazine
- penicillamine
Some anticonvulsants, including valproic acid, carbamazepine, and phenytoin, can also increase the catabolism of vitamin B6 and lead to a deficiency. (1)
Reference
- Linnebank M et al. Antiepileptic drugs and vitamin B6 plasma levels in adult patients. Epilepsy Res. 2012 Aug;101(1-2):182-4
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