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Fructose intolerance

Authoring team

Fructose intolerance is caused by deficiency of the enzyme fructose-1-phosphate aldolase. Inherited as an autosomal recessive condition, it manifests with symptoms of hypoglycaemia after the ingestion of fructose, the result of accumulation of fructose-1-phosphate.

Diagnosis is confirmed by the measurement of the enzyme in the liver.

Treatment is with a fructose-free diet, which if adhered to, is concordant with a good prognosis.

Reference

  1. Gibson P et al. 2007 . Review article: Fructose malabsorption and the bigger picture . Aliment Pharmacol Ther. , 25 : 349 – 363

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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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