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Regulation (oxoglutarate dehydrogenase)

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Oxoglutarate dehydrogenase is a non-equilibrium, flux-generating reaction within the tricarboxylic acid cycle.

It is stimulated by:

  • increasing concentration of ADP relative to ATP
  • increasing concentration of NAD relative to NADH
  • increasing concentration of coenzyme A relative to succinyl-CoA
  • increasing calcium concentration

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