This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Chromosomal abnormality screening

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

The risk of aneuploidies such as trisomy 21 tend to increase with age. For example, the risk of Down's syndrome at the 16th week to a 25-year-old woman is 1 in 1000, whereas the risk for a 42-year-old-woman is 1 in 50.

All major chromosomal abnormalities may be excluded by amniocentesis with fetal karyotyping. The general recommendation is that amniocentesis should be offered to women who will be aged greater than 35 years and over at their estimated time of confinement. Invasive procedures like amniocentesis is not recommended to be offered to women based on their aged alone risk. In 2006 only 4% of women were reported on having a diagnostic procedure based on age alone.

There were 1877 Downs syndrome diagnosis in 2006 for England and Wales, 60% (1132) (2) were diagnosed prenatal. With increased performance of screening tests diagnostic procedures are reducing, in the last 3 years they have reduced by 6000 while the prenatal detection rate is steadily increasing (1).

Reference for above:

  • 1. Figures supplied to FASP from the National Down's syndrome Cytogenetic Register
  • 2. Down's Syndrome Report 2007 Accessed at www.wolfson.qmul.ac-uk/ndscr

Related pages

Create an account to add page annotations

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.