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Investigations in haemolytic disease of the newborn

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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If haemolytic disease of the newborn is suspected, the following investigations should be carried out:

  • full blood count, with attention to haemoglobin, white cells and reticulocytes
  • platelets
  • infant blood group and Coombs test
  • maternal blood group and haemolysins
  • red cell enzyme assay may be a helpful second line investigation
  • blood film and osmolar fragility may diagnose spherocytosis

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