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Addison's disease or primary adrenocortical deficiency results from destruction of the adrenal cortex. Glucocorticoid, mineralocorticoid and sex steroid production are all reduced.
It is a rare condition with a prevalence of 93-140 per million people and an annual incidence of 4.7-6.2 per million people in Western populations (1).
Autoimmune adrenalitis accounts increasingly for the condition as tuberculosis has become less common.
The disease may remain subclinical for a long period of time (4).