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Autosomal dominant cerebellar ataxia

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

This is a heterogeneous group of adult-onset progressive ataxias which have an autosomal dominant mode of inheritance. There is often a widespread neuronal degeneration which resembles multiple system atrophy.

There are three main clinical groups:

  • spinocerebellar ataxia type 1
  • spinocerebellar ataxia type 2
  • Machado-Joseph syndrome
  • cerebellar cortical degeneration

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