Caudal regression sequence
The caudal regression sequence describes a particular pattern of malformation which is frequently associated with maternal diabetes in pregnancy.
The sequence includes, to a variable degree:
- incomplete development of the sacrum and lumbar vertebrae; the extreme being sacral agenesis
- femoral hypoplasia - reduced growth of the caudal region
- neural tube defects, with disruption of the spinal cord distally
Clinically any of the sequelae of these may be noted, in addition to which a frequent feature is flattened buttocks.
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