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Hyperfiltration damage

Authoring team

Once a significant proportion of the nephrons have been destroyed renal function continues to deteriorate independent of the original pathology. Histology will demonstrate a characteristic picture of glomerulosclerosis.

Factors which accelerate the deterioration in renal function include:

  • glomerular hyperperfusion and hyperfiltration
  • a high protein diet
  • hypertension
  • hyperphosphataemia

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