Neonatal hyperthyroidism
This uncommon condition results from transplacental passage of stimulating IgG TSH-receptor antibodies to the infant from a mother with a past or current history of Graves' disease.
The maternal concentration of stimulating TSH-receptor antibodies must be high for the neonate to be affected and maternal pre-tibial myxoedema serves a useful marker of the maternal state.
Reference
- Batra CM. Fetal and neonatal thyrotoxicosis. Indian J Endocrinol Metab. 2013 Oct;17(Suppl 1):S50-4
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