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Severe combined immunodeficiency disease

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Severe combined immunodeficiency disease is a heterogenous group of autosomal or X linked recessive disorders characterised by markedly decreased T and B cell function. Defects in the normal ossification of foetal cartilage (dysostosis) and adenosine deaminase deficiency are common.

The overall incidence of SCID is 2 per million, but the rate is higher in some groups, for example, Apache Indians.

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