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Topiramate and ocular syndrome

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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  • an ocular syndrome has been reported associated with the use of topiramate - the syndrome is characterised by acute myopia and secondary angle-closure glaucoma

  • as of August 17, 2001, there had been 23 reported cases of this ocular syndrome; 22 in adults and 1 in a paediatric patient. This information was base on the post marketing experience in more than 825,000 patients (1)

  • symptoms of ocular syndrome generally occur within 1 month of the start of treatment and include decreased visual acuity and/or ocular pain. Ophthalmological findings include hyperaemia, bilateral myopia, anterior chamber shallowing, and increased intra-ocular pressure with or without mydriasis. Also there may also be supraciliary effusion resulting in anterior displacement of lens and iris. Treatment includes discontinuation of topiramate treatment as rapidly as is clinically feasible and appropriate measures to reduce intraocular pressure

  • please consult summary of product characteristics for more details


  • (1) Janssen-Cilag Ltd (15/10/2001). Letter - Important Safety Information - Topamax (R) Tablets and Topamax (R) Sprinkle Capsules (Topiramate).

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