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Celecoxib versus diclofenac trial

Authoring team

The trial enrolled 655 patients with adult-onset rheumatoid arthritis and compared the anti-inflammatory efficacy and the gastrointestinal side-effects of celecoxib versus diclofenac.

The trial had a double-blind, double-dummy, randomised, parellel design.

Anti-inflammatory effects were assessed every four weeks for 24 weeks. 430 patients received an upper GI endoscopy to assess the presence of ulceration.

Reference:

  • Emery, P. et al. (1999) "Celecoxib versus diclofenac in long-term management of rheumatoid arthritis: randomised double-blind comparison". Lancet, 354, 2106-11.

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