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Switching antidepressant (mirtazapine to agomelatine) in adults

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Mirtazapine to agomelatine

Cross-taper

  • cross-tapering can usually be undertaken cautiously over 2 to 4 weeks, the speed is determined by individual tolerability

  • is limited experience with this switch so extra caution is required. Although interactions are not expected, agomelatine is not expected to mitigate discontinuation reactions from stopping mirtazapine.

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