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Switching antidepressant (mirtazapine to tricyclic antidepressants (TCAs)) in adults

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Mirtazapine to tricyclic antidepressants (TCAs)

  • Switching to dosulepin requires specialist advice and should not be done in primary care due to the increased cardiac risk and toxicity in overdose.

Cross-taper

  • cross-tapering can usually be undertaken cautiously over 2 to 4 weeks, the speed is determined by individual tolerability

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