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Switching antidepressant - SNRI (e.g. duloxetine or venlafaxine) to agomelatine in adults

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SNRIs to agomelatine

Cross-taper

  • cross-tapering can usually be undertaken cautiously over 2 to 4 weeks, the speed is determined by individual tolerability
  • is limited experience with this switch so extra caution is required. Although interactions are not expected, agomelatine is not expected to mitigate discontinuation reactions from stopping the SNRI

Reference:

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