Switching antidepressant - SNRI (e.g. duloxetine or venlafaxine) to moclobemide in adults
SNRIs to moclobemide
Taper, washout and switch
- gradually reduce the dose of the SNRI and stop; wait 7 days before starting moclobemide
- cross-tapering is not recommended due to the high risk of serotonin syndrome
Reference:
- NHS Specialist Pharmacy Service (February 2023). SNRIs to other antidepressants: switching in adults
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