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Switching antidepressant - SNRI (e.g. duloxetine or venlafaxine) to vortioxetine in adults

Authoring team

SNRIs to vortioxetine

  • is limited experience with this switch so extra caution is required to avoid serotonin syndrome.

Direct switch

  • a direct switch, i.e. stopping one medicine and then starting the new medicine the following day, is normally possible.

Taper, washout and switch

  • alternatively, gradually reduce the dose of the SNRI and stop; wait for a period before starting vortioxetine. Clinicians should decide the duration of the washout period on a case-by-case basis.

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