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Switching antidepressant (tricyclic antidepressants (TCA) to agomelatine) in adults

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Switching antidepressant (tricyclic antidepressants (TCA) to agomelatine)

Cross-taper

  • cross-tapering can usually be undertaken cautiously over 2 to 4 weeks, the speed is determined by individual tolerability

  • there is limited experience with this switch so extra caution is required. Although interactions are not expected, agomelatine is not expected to mitigate discontinuation reactions from stopping TCAs.

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