Switching antidepressant (tricyclic antidepressants (TCA) to agomelatine) in adults
Switching antidepressant (tricyclic antidepressants (TCA) to agomelatine)
Cross-taper
- cross-tapering can usually be undertaken cautiously over 2 to 4 weeks, the speed is determined by individual tolerability
- there is limited experience with this switch so extra caution is required. Although interactions are not expected, agomelatine is not expected to mitigate discontinuation reactions from stopping TCAs.
Reference:
- NHS Specialist Pharmacy Service (February 2023). Tricyclics to other antidepressants: switching in adults
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