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Switching antidepressant (tricyclic antidepressants (TCA) to another TCA) in adults

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Switching antidepressant (tricyclic antidepressants (TCA) to another TCA)

From all except clomipramine

Direct switch

  • a direct switch, i.e. stopping one medicine and then starting the new medicine the following day, is normally possible

From clomipramine

Cross-taper

  • cross-tapering can usually be undertaken cautiously over 2 to 4 weeks, the speed is determined by individual tolerability

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