Switching antidepressant (tricyclic antidepressants (TCA) to another TCA) in adults

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Switching antidepressant (tricyclic antidepressants (TCA) to another TCA)

switching to dosulepin requires specialist advice and should not be done in primary care

 due to the increased cardiac risk and toxicity in overdose.

a direct switch, i.e. stopping one medicine and then starting the new medicine the following day, is normally possible

cross-tapering can usually be undertaken cautiously over 2 to 4 weeks, the speed is determined by individual tolerability

NHS Specialist Pharmacy Service (February 2023). 

Tricyclics to other antidepressants: switching in adults

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Switching antidepressant (tricyclic antidepressants (TCA) to another TCA) in adults

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