Switching antidepressant (tricyclic antidepressants (TCA) to vortioxetine)
There is limited experience with this switch so extra caution is required to avoid serotonin syndrome.
From all except clomipramine
Cross-taper
Cross-tapering can usually be undertaken cautiously over 2 to 4 weeks, the speed is determined by individual tolerability. It should include:
Taper, washout and switch
From clomipramine
Taper, stop and switch
Taper, washout and switch
Reference:
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