Last reviewed dd mmm yyyy. Last edited dd mmm yyyy
Switching antidepressant (tricyclic antidepressants (TCA) to vortioxetine)
There is limited experience with this switch so extra caution is required to avoid serotonin syndrome.
From all except clomipramine
Cross-taper
Cross-tapering can usually be undertaken cautiously over 2 to 4 weeks, the speed is determined by individual tolerability. It should include:
Taper, washout and switch
From clomipramine
Taper, stop and switch
Taper, washout and switch
Reference:
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