Switching antidepressant (vortioxetine to moclobemide) in adults
Vortioxetine to moclobemide
Taper, washout and switch
- gradually reduce the dose of vortioxetine and stop; wait 7 days before starting low dose moclobemide
- cross-tapering is not recommended due to the high risk of serotonin syndrome
- is limited experience with this switch so extra caution is required to avoid serotonin syndrome (1)
Reference:
- NHS Specialist Pharmacy Service (February 2023). Vortioxetine to other antidepressants: switching in adults
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