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Switching antidepressant (vortioxetine to serotonin and noradrenaline reuptake inhibitors (SNRIs) (e.g. duloxetine or venlafaxine)) in adults

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Vortioxetine to serotonin and noradrenaline reuptake inhibitors (SNRIs)

  • is limited experience with this switch so extra caution is required to avoid serotonin syndrome

Direct switch

  • a direct switch, i.e. stopping one antidepressant and then starting the new antidepressant the following day, is normally possible

Stop, washout and switch

  • alternatively, stop vortioxetine; wait for a period before starting the SNRI. Clinicians should decide the duration of the washout period on a case-by-case basis


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