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Switching antidepressant (vortioxetine to trazodone) in adults

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Vortioxetine to trazodone

  • is limited experience with this switch so extra caution is required to avoid serotonin syndrome.


  • cross-tapering can usually be undertaken cautiously over 2 to 4 weeks, the speed is determined by individual tolerability

Stop, washout and switch

  • alternatively, stop vortioxetine; wait for a period before starting trazodone. Clinicians should decide the duration of the washout period on a case-by-case basis


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