when a study has a comparator intervention against an active control, it is important that any comparisons that are made are fair
if a drug of interest was being compared with a control drug with respect to side effects then it would be an unfair comparison if a low dose of a drug of interest was compared with a high dose of a control drug because will have the effect of minimising the risk of side effects from the drug of interest and potentially maximising the harms seen with the control drug
if a drug of interest was compared with a control drug with respect to efficacy then an unfair comparison would be to compare a high dose of the drug of interest with a low dose of an active control drug - this would potentially maximise the efficacy of the drug of interest, but may minimise the efficacy of the control drug
Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page