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Ca125 (Ca - 125) - NICE urgent cancer referral guidance

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team


Investigation findings and specific features

Possible Cancer


Serum CA125 results


If serum CA125 is 35 IU/ml or greater, arrange an ultrasound scan of the abdomen and pelvis

  • normal serum CA125 (less than 35 IU/ ml), or CA125 of 35 IU/ml or greater but a normal ultrasound:
    • assess her carefully for other clinical causes of her symptoms and investigate if appropriate
    • if no other clinical cause is apparent, advise her to return to her GP if her symptoms become more frequent and/or persistent


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