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Aetiology

Authoring team

The aetiology of this condition is unknown.

Goodpasture's syndrome often starts after an upper respiratory tract infection (there is an association with influenza A2 virus)

  • during the 1919 influenza epidemic, Goodpasture described a disease association between pulmonary hemorrhage and rapidly progressive glomerulonephritis (RPGN)
    • in 1977, Lerner et al. discovered that the sera and/or kidneys of some patients with this syndrome contained antibodies against the glomerular basement membrane

There is a strong association with HLA-DR2 (about 90%). A more severe form of the disease occurs in patients who also have HLA-B7.

Reference:

  1. E. Goodpasture. The significance of certain pulmonary lesions in relation to the etiology of influenza. Am J Med Sci 1919; 158:863–870

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