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Honeymoon cystitis

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Honeymoon cystitis

  • the pathogenic role of S. saprophyticus in UTIs (sometimes referred to as "honeymoon cystitis") was described in the 1960s and since then, more and more evidence was found regarding the pathogenesis of this disease (1)
    • most of epidemiological studies estimate S. saprophyticus as causative agents in 5-20% of UTIs, however, a study from Sweden found that this pathogen
      was the etiological agent in > 40% of uncomplicated UTIs in females

  • Staphylococcus saprophyticus
    • is a Gram-positive, coagulase-negative, non-hemolytic coccus that is a common cause of uncomplicated urinary tract infections (UTIs), particularly in young sexually active females (2)
    • is the second most common cause of community-acquired urinary tract infections, after Escherichia coli
    • over 40% of all young, sexually active women contain S. saprophyticus as part of their normal genitourinary flora (2)

  • antibiotic of choice in uncomplicated S. saprophyticus UTIs is nitrofurantoin 100 mg orally twice daily for five days, or for seven days in complicated cases (2)


  • Gajdacs M et al. Increasing relevance of Gram-positive cocci in urinary tract infections: a 10-year analysis of their prevalence and resistance trends.Sci Rep 10, 17658 (2020).
  • Ehlers S, Merrill SA. Staphylococcus Saprophyticus. [Updated 2021 Jul 1]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-.

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