Reduced transfer with normal ventilation
The causes of a reduced transfer factor in the presence of normal ventilatory function include:
- interstitial lung disease
- pulmonary vascular disease
- anaemia
Notes:
- with respect to interstitial lung disease, the classic restrictive picture is of normal or even elevated FEV1/FVC ratio. However, absolute values for both FEV1 and FVC will decrease (1)
Reference:
- Verbanck S et al. Transfer factor, lung volumes, resistance and ventilation distribution in healthy adults. European Respiratory Journal 2015 47(1): 166-176
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