This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Latent autoimmune diabetes of adults (LADA)

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

  • a subgroup of patients diagnosed earlier as type 2 diabetes (around 12%) (1) has circulating autoantibodies
    • circulating autoantibodies are to islet cell cytoplasmatic antigens (ICA) and more frequently to glutamic acid decarboxilase (GAD, GADab) (2)

  • patients were reported earlier as type 1 diabetes, but according to the WHO Classification of diabetes mellitus it is called now Latent Autoimmune Diabetes in Adults (LADA) (3 and 4)
    • LADA could be a part of the type 2 diabetes since its onset is in the adulthood,
      • LADA shows some characteristics of type 2 diabetes, which is a heterogenous disease that results from a combination of abnormalities in both insulin secretion and insulin action
    • LADA cases are usually with genuine insulin deficiency, many are non-obese with a beta-cell secretory defect (3). This compares with other cases of type 2 diabetes where hyperinsulinaemia is a characteristic feature
    • in consideration of the genetic factors influencing the development of LADA (5):
      • the most important genetic risk factors for LADA is heterozygosity for DR3-DQ2/DR4-DQ8 followed by heterozygosity for MICA5.0/5.1, and finally to some extent homozygosity for DR3-DQ2
      • DR15-DQ6 is a protective factor for type 1 diabetes and to some extent for LADA

  • some alternate the terms LADA and type 1.5 diabetes (6)
    • people diagnosed with LADA are usually over age 30

Reference:

  1. M. Pietropaolo et al.Evidence of Islet cell autoimmunitiy in elderly patients with Type 2 diabetes. Diabetes 49 (2000): 32-38.
  2. T. Tuomi et al.Clinical and genetic characteristics of type 2 diabetes with and without GAD antibodies. Diabetes 48 (1999): 150–157.
  3. P.Z. Zimmet et al.atent autoimmune diabetes mellitus in adults (LADA): the role of autoantibodies to glutamic acid decarboxilase in diagnosis and prediction of insulin dependency. Diabetic Med. 11 (1994):299–303.
  4. for the WHO consultation, K.G.M.M. Alberti and P.Z. Zimmet , Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional Report of a WHO consultation. Diabetic Med. 15 1998 (1998), pp. 539–553.
  5. Torn C et al. Heterozygosity for MICA5.0/MICA5.1 and HLA-DR3-DQ2/DR4-DQ8 are independent genetic risk factors for latent autoimmune diabetes. Human Immunology (2003); 64 (9): 902-909.
  6. "Latent autoimmune diabetes". Mayo Clinic. Retrieved September 28th, 2016.

Related pages

Create an account to add page annotations

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.