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Acute inflammatory response in asthma

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The acute inflammatory response is characterised by bronchoconstriction and airways oedema. This process begins within minutes of allergen exposure and resolves within hours.

Cross-linking of mast cell-bound IgE by allergen results in degranulation and the release of:

  • histamine:
    • causes increased blood flow and vascular permeability

  • proteases:
    • promote tissue degradation

  • tissue necrosis factor:
    • activates endothelial cells and promotes migration of inflammatory cells

  • platelet activating factor and leukotrienes:
    • promote smooth muscle contraction and mucus secretion

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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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