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Quaternary ammonium compounds

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Quaternary ammonium compounds are antimuscarinic compounds that are less lipid soluble than atropine, and thus may be less likely to cross the blood-brain barrier. They are less well absorbed than atropine.

The central side effects are reduced with respect to atropine, but the peripheral effects remain common at therapeutic doses.

Quaternary ammonium compounds include:

  • ipratropium bromide
  • hyoscine butylbromide
  • mepenzolate bromide
  • pipenzolate bromide
  • poldine methylsulphate
  • propantheline bromide

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