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Treatment of staphylococcal pneumonia

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Antibiotic treatment should be started after blood and sputum has been taken for culture. Initial therapy is often blind.

Consult with a bacteriologist about appropriate drug treatment if in doubt:

  • penicillin-sensitive
    • first choice: amoxicillin
    • alternative: doxycycline or clarithromycin

  • penicillinase producing
    • first choice: flucloxacillin
    • alternative: dependent on local sensitivities

Treatment for staphylococcal pneumonia may be with flucloxacillin 250 mg 4 times daily by mouth or IV until improvement. In severe infections, doses may be doubled.


Pneumonia (community-acquired): antimicrobial prescribing. NICE guideline [NG138]Published: 16 September 2019

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