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Gliadin (antibodies)

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Anti-gliadin antibody is a screening test for coeliac disease and dermatitis herpetiformis.

Anti-gliadin antibody, IgA, test:

  • sensitivity: 75-95%
  • specificity: 80-95%
  • note that IgG is less specific and sensitive, but may be present if the patient is IgA deficient - a known association with coeliac disease

Sensitivity of anti-gliadin is reduced in children under 4 years for coeliac/dermatitis herpetiformis.

The presently available serological tests cannot substitute for a diagnostic biopsy (1,2).

Reference:

  1. Scand. J. Gastro. 1994; 29(5): 452
  2. Rostom A et al. The diagnostic accuracy of serologic tests for celiac disease: a systematic review. Gastroenterology 2005;128:S38-46

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