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Methotrexate and statins

Authoring team

Liver toxicity

 

  • taking methotrexate and statins (for example, atorvastatin or simvastatin) can increase the risk of liver toxicity

Suggested management options (1):

  • no additional action is required
  • routine monitoring of methotrexate should detect any signs of liver toxicity

Reference:

  1. NHS Specialist Pharmacy Service (June 30th 2025). Managing interactions with methotrexate

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